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Application of sentinel lymph node biopsy in patients with melanoma.

Abstract The findings suggest that immunohistochemistry could effectively improve the detection of positive SLN in melanoma. Cases with SLN metastatic deposits ≤2 mm are less likely to have further metastases in NSLN. There is a need for prospective large-population based studies to identify a subgroup of SLN positive patients who can safely be spared complete lymph node dissection.
PMID
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Authors

Mayor MeshTerms

Sentinel Lymph Node Biopsy

Keywords

Immunohistochemistry

Malignant melanoma

Sentinel lymph node

Tumor burden

Journal Title zhonghua bing li xue za zhi = chinese journal of pathology
Publication Year Start




PMID- 29783803
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20180611
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 5
DP  - 2018 May 8
TI  - [Application of sentinel lymph node biopsy in patients with melanoma].
PG  - 360-365
LID - 10.3760/cma.j.issn.0529-5807.2018.05.009 [doi]
AB  - Objective: To investigate the difference between routine hematoxylin-eosin (HE)
      staining and immunohistochemistry in diagnosing metastatic melanoma in sentinel
      lymph node (SLN) metastases, and to evaluate the association of SLN tumor burden 
      with the status of non-sentinel lymph nodes (NSLN). Methods: 126 melanoma
      patients were treated with SLN biopsy and further examined with
      immunohistochemistry at Fudan University Shanghai Cancer Center between 2010 and 
      2016, and the status of SLN was respectively estimated by HE stain and
      immunohistochemistry (S-100 protein, HMB45, Melan A and SOX10). In 39 patients
      who were treated with complete lymph node dissection, characteristics of SLN
      tumor burden (maximum diameter of the tumor deposit, tumor penetrative depth and 
      the microanatomic location of the metastasis) and the associations of SLN tumor
      burden with the involvement of NSLN were all evaluated. Results: Of the total 126
      cases, 33 (26.2%) were positive by HE staining and 49 (38.3%) were positive by
      immunohistochemistry. S-100 protein was positive in 48 out of 49 cases (98.0%).
      HMB45 was positive in 46 out of 49 cases (93.9%). Melan A was positive in 47 out 
      of 49 cases (96.0%). SOX10 was positive in 8 out of 8 cases. The outcome
      indicated that the application of immunohistochemistry identified positive SLN
      missed by HE stain in about 12.1% of cases. Of the 39 patients who were treated
      with complete lymph node dissection, six showed metastases in NSLN. The frequency
      of metastases in NSLN was 15.4% (6/39) when SLN was positive. Additionally, the
      frequency of metastases in NSLN in cases with SLN metastatic deposits &lt;/=2 mm was
      significantly lower than that in cases with SLN metastatic deposits &gt;2 mm; eight 
      cases with SLN metastatic deposits &lt;0.2 mm had no additional positive NSLN.
      Conclusions: The findings suggest that immunohistochemistry could effectively
      improve the detection of positive SLN in melanoma. Cases with SLN metastatic
      deposits &lt;/=2 mm are less likely to have further metastases in NSLN. There is a
      need for prospective large-population based studies to identify a subgroup of SLN
      positive patients who can safely be spared complete lymph node dissection.
FAU - Ren, M
AU  - Ren M
AD  - Department of Pathology, Shanghai Cancer Center, Fudan University and Department 
      of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Kong, Y Y
AU  - Kong YY
FAU - Cai, X
AU  - Cai X
FAU - Shen, X X
AU  - Shen XX
FAU - Lyu, J J
AU  - Lyu JJ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Coloring Agents)
RN  - 0 (MART-1 Antigen)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (S100 Proteins)
RN  - 0 (SOXE Transcription Factors)
RN  - TDQ283MPCW (Eosine Yellowish-(YS))
RN  - YKM8PY2Z55 (Hematoxylin)
SB  - IM
MH  - China
MH  - Coloring Agents
MH  - Eosine Yellowish-(YS)
MH  - Hematoxylin
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymph Node Excision
MH  - Lymphatic Metastasis
MH  - MART-1 Antigen/analysis
MH  - Melanoma/chemistry/*pathology
MH  - Neoplasm Proteins/analysis
MH  - Prospective Studies
MH  - S100 Proteins/analysis
MH  - SOXE Transcription Factors/analysis
MH  - *Sentinel Lymph Node Biopsy
MH  - Skin Neoplasms/chemistry/*pathology
MH  - Tumor Burden
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - Malignant melanoma
OT  - Sentinel lymph node
OT  - Tumor burden
EDAT- 2018/05/23 06:00
MHDA- 2018/06/12 06:00
CRDT- 2018/05/23 06:00
PHST- 2018/05/23 06:00 [entrez]
PHST- 2018/05/23 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 May 8;47(5):360-365.