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Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy.

Abstract Osteoradionecrosis of the jaw (ORNJ) is the most severe and complex sequel of head and neck radiotherapy (RT) because of the bone involved, it may cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra oral communication and pathological fracture. We treated twenty lesions of ORNJ using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy (aPDT). The objective of this study was to stimulate the affected area to homeostasis and to promote the healing of the oral mucosa.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title journal of applied oral science : revista fob
Publication Year Start




PMID- 29791570
OWN - NLM
STAT- MEDLINE
DCOM- 20180530
LR  - 20180530
IS  - 1678-7765 (Electronic)
IS  - 1678-7757 (Linking)
VI  - 26
DP  - 2018
TI  - Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser
      therapy and antimicrobial photodynamic therapy.
PG  - e20170172
LID - S1678-77572018000100455 [pii]
LID - 10.1590/1678-7757-2017-0172 [doi]
AB  - BACKGROUND: Osteoradionecrosis of the jaw (ORNJ) is the most severe and complex
      sequel of head and neck radiotherapy (RT) because of the bone involved, it may
      cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra
      oral communication and pathological fracture. We treated twenty lesions of ORNJ
      using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy
      (aPDT). The objective of this study was to stimulate the affected area to
      homeostasis and to promote the healing of the oral mucosa. METHODS: We performed 
      aPDT on the exposed bone, while LLLT was performed around the bone exposure (red 
      spectrum) and on the affected jaw (infrared spectrum). Monitoring and clinical
      intervention occurred weekly or biweekly for 2 years. RESULTS: 100% of the sample
      presented clinical improvement, and 80% presented complete covering of the bone
      exposure by intact oral mucosa. CONCLUSION: LLLT and aPDT showed positive results
      as an adjuvant therapy to treat ORNJ.
FAU - Ribeiro, Guilherme Henrique
AU  - Ribeiro GH
AD  - Nucleo de Odontologia Hospitalar do Hospital Universitario, Universidade Federal 
      de Santa Catarina, Florianopolis, SC, Brasil.
FAU - Minamisako, Mariana Comparotto
AU  - Minamisako MC
AD  - Servico de Odontologia do Centro de Pesquisas Oncologicas de Santa Catarina,
      Florianopolis, SC, Brasil.
FAU - Rath, Ines Beatriz da Silva
AU  - Rath IBDS
AD  - Nucleo de Odontologia Hospitalar do Hospital Universitario, Universidade Federal 
      de Santa Catarina, Florianopolis, SC, Brasil.
FAU - Santos, Aira Maria Bonfim
AU  - Santos AMB
AD  - Nucleo de Odontologia Hospitalar do Hospital Universitario, Universidade Federal 
      de Santa Catarina, Florianopolis, SC, Brasil.
FAU - Simoes, Alyne
AU  - Simoes A
AD  - Departamento de Biomateriais e Biologia Oral, Universidade de Sao Paulo, Sao
      Paulo, SP, Brasil.
FAU - Pereira, Keila Cristina Rausch
AU  - Pereira KCR
AD  - Departamento de Odontologia, Universidade do Sul de Santa Catarina, Palhoca, SC, 
      Brasil.
FAU - Grando, Liliane Janete
AU  - Grando LJ
AD  - Nucleo de Odontologia Hospitalar do Hospital Universitario, Universidade Federal 
      de Santa Catarina, Florianopolis, SC, Brasil.
LA  - eng
PT  - Evaluation Studies
PT  - Journal Article
DEP - 20180521
PL  - Brazil
TA  - J Appl Oral Sci
JT  - Journal of applied oral science : revista FOB
JID - 101189774
RN  - 0 (Anti-Infective Agents)
SB  - D
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Infective Agents/*therapeutic use
MH  - Chemoradiotherapy, Adjuvant/*methods
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Homeostasis/drug effects/radiation effects
MH  - Humans
MH  - Jaw Diseases/pathology/*therapy
MH  - Low-Level Light Therapy/*methods
MH  - Male
MH  - Middle Aged
MH  - Mouth Mucosa/drug effects/radiation effects
MH  - Osteoradionecrosis/pathology/*therapy
MH  - Photochemotherapy/*methods
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Time Factors
MH  - Treatment Outcome
MH  - Wound Healing/radiation effects
PMC - PMC5953563
EDAT- 2018/05/24 06:00
MHDA- 2018/05/31 06:00
CRDT- 2018/05/24 06:00
PHST- 2017/04/24 00:00 [received]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/05/24 06:00 [entrez]
PHST- 2018/05/24 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - S1678-77572018000100455 [pii]
AID - 10.1590/1678-7757-2017-0172 [doi]
PST - ppublish
SO  - J Appl Oral Sci. 2018;26:e20170172. doi: 10.1590/1678-7757-2017-0172. Epub 2018
      May 21.