Efficacy comparison between primary total laryngectomy and nonsurgical organ-preservation strategies in treatment of advanced stage laryngeal cancer: A meta-analysis.
|Abstract||We aimed to provide a pooled analysis of controlled trials comparing long-term survival after primary laryngectomy and primary organ preservation methods in patients with T3-4 laryngeal cancer.|
Comparison of the therapeutic effects of total laryngectomy and a larynx-preservation approach in patients with T4a laryngeal cancer and thyroid cartilage invasion: A multicenter retrospective review.
|Publication Year Start||2018-01-01|
PMID- 29794737 OWN - NLM STAT- MEDLINE DCOM- 20180612 LR - 20180612 IS - 1536-5964 (Electronic) IS - 0025-7974 (Linking) VI - 97 IP - 21 DP - 2018 May TI - Efficacy comparison between primary total laryngectomy and nonsurgical organ-preservation strategies in treatment of advanced stage laryngeal cancer: A meta-analysis. PG - e10625 LID - 10.1097/MD.0000000000010625 [doi] AB - BACKGROUND: We aimed to provide a pooled analysis of controlled trials comparing long-term survival after primary laryngectomy and primary organ preservation methods in patients with T3-4 laryngeal cancer. METHODS: We performed random-effects meta-analyses on overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and locoregional control (LRC). RESULTS: Fifteen studies met the selection criteria including 6288 patients (2696 patients who underwent primary laryngectomy and 3592 patients who underwent primary nonsurgical organ preservation therapy). There was a significant difference between the groups with respect to OS (HR 0.71, 95% CI 0.57-0.89, P = .003). However, a subgroup analysis found OS was not significantly worse for patients with T3 laryngeal cancer who received primary organ preservation compared with patients who underwent primary laryngectomy (HR 0.96, 95% CI 0.45-2.03, P = .91). There was no significant difference for DFS (HR 0.63, 95% CI 0.39-1.04, P = .07) in two groups. Patients with laryngeal cancer who underwent primary laryngectomy had a better DSS (HR 0.47, 95% CI 0.25-0.88, P = .02) and LRC (HR 0.56, 95% CI 0.390.80, P = .001) than patients who underwent primary nonsurgical organ preservation therapy. CONCLUSION: Our results support total laryngectomy for patients with T4 laryngeal cancer and show that primary organ preservation for laryngeal cancer has no advantage and also did not decrease the rate of OS in patients with T3 laryngeal cancer when compared with primary total laryngectomy. FAU - Tang, Zhao-Xian AU - Tang ZX AD - Department of ENT, Chongqing Cancer Hospital and Institute and Cancer Center, Chongqing, China. FAU - Gong, Jing-Lin AU - Gong JL FAU - Wang, Ya-Hui AU - Wang YH FAU - Li, Zhen-Hua AU - Li ZH FAU - He, Yun AU - He Y FAU - Liu, Yi- Xiu AU - Liu YX FAU - Zhou, Xiao-Hong AU - Zhou XH LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - AIM SB - IM MH - Humans MH - Laryngeal Neoplasms/mortality/pathology/*surgery MH - Laryngectomy/*methods MH - Larynx/pathology/surgery MH - Organ Preservation/*methods MH - Survival Rate MH - Treatment Outcome EDAT- 2018/05/26 06:00 MHDA- 2018/06/13 06:00 CRDT- 2018/05/26 06:00 PHST- 2018/05/26 06:00 [entrez] PHST- 2018/05/26 06:00 [pubmed] PHST- 2018/06/13 06:00 [medline] AID - 10.1097/MD.0000000000010625 [doi] AID - 00005792-201805250-00013 [pii] PST - ppublish SO - Medicine (Baltimore). 2018 May;97(21):e10625. doi: 10.1097/MD.0000000000010625.