PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Low preoperative fibrinogen level is risk factor for neurological complications in acute aortic dissection.

Abstract Aortic arch surgery in patients with acute aortic dissection is frequently complicated by neurological complications and coagulopathy. However, the relationship between the coagulation system and neurological complications in patients with acute aortic dissection has not been clarified. Thus, the aim of this study was to investigate the relationship between the coagulation system and neurological complications in patients with acute aortic dissection.From September 2014 to January 2016, a total of 126 patients with acute type A aortic dissection were enrolled. Perioperative characteristics and standard laboratory tests upon admission were analyzed using univariate and multivariate logistic regression analysis in this study. The primary outcome was the correlation between the coagulation system and neurological complications.Univariate logistic regression analysis showed that the neurological complications (+) group underwent more serious and complicated postoperative outcomes. Multivariable logistic regression analysis revealed serum creatinine level (OR, 1.049; 95% CI, 1.011-1.089; P = .01), white blood cell counts (OR, 1.581; 95% CI, 1.216-2.057; P = .001) and fibrinogen concentration upon admission (OR, 0.189; 95% CI, 0.060-0.596; P = .004) as predictors of neurological complications. However, we found that there was no association between the coagulation system and in-hospital mortality.Low preoperative fibrinogen level is the preferred marker for predicting clinical neurological complications in patients with acute type A aortic dissection treated with surgical repair.
PMID
Related Publications

Results of immediate surgical treatment of all acute type A dissections.

Consumption coagulopathy in acute aortic dissection: principles of management.

Evaluation of risk factors for transient neurological dysfunction and adverse outcome after repair of acute type A aortic dissection in 122 consecutive patients.

Risk of development of neurological complications in prosthetic repair of the aortic ascending portion and arch.

Changes in the Hemostatic System of Patients With Acute Aortic Dissection Undergoing Aortic Arch Surgery.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29794773
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 21
DP  - 2018 May
TI  - Low preoperative fibrinogen level is risk factor for neurological complications
      in acute aortic dissection.
PG  - e10830
LID - 10.1097/MD.0000000000010830 [doi]
AB  - Aortic arch surgery in patients with acute aortic dissection is frequently
      complicated by neurological complications and coagulopathy. However, the
      relationship between the coagulation system and neurological complications in
      patients with acute aortic dissection has not been clarified. Thus, the aim of
      this study was to investigate the relationship between the coagulation system and
      neurological complications in patients with acute aortic dissection.From
      September 2014 to January 2016, a total of 126 patients with acute type A aortic 
      dissection were enrolled. Perioperative characteristics and standard laboratory
      tests upon admission were analyzed using univariate and multivariate logistic
      regression analysis in this study. The primary outcome was the correlation
      between the coagulation system and neurological complications.Univariate logistic
      regression analysis showed that the neurological complications (+) group
      underwent more serious and complicated postoperative outcomes. Multivariable
      logistic regression analysis revealed serum creatinine level (OR, 1.049; 95% CI, 
      1.011-1.089; P = .01), white blood cell counts (OR, 1.581; 95% CI, 1.216-2.057; P
      = .001) and fibrinogen concentration upon admission (OR, 0.189; 95% CI,
      0.060-0.596; P = .004) as predictors of neurological complications. However, we
      found that there was no association between the coagulation system and
      in-hospital mortality.Low preoperative fibrinogen level is the preferred marker
      for predicting clinical neurological complications in patients with acute type A 
      aortic dissection treated with surgical repair.
FAU - Guan, Xinliang
AU  - Guan X
AD  - Department of Cardiac Surgery, Beijing Aortic Disease Center, Beijing Anzhen
      Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood
      Vessel Diseases, Beijing Lab for Cardiovascular Precision Medicine, and Beijing
      Engineering Research Center of Vascular Prostheses, Beijing, China.
FAU - Gong, Ming
AU  - Gong M
FAU - Wang, Xiaolong
AU  - Wang X
FAU - Zhu, Junming
AU  - Zhu J
FAU - Liu, Yongmin
AU  - Liu Y
FAU - Sun, Lizhong
AU  - Sun L
FAU - Zhang, Hongjia
AU  - Zhang H
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 9001-32-5 (Fibrinogen)
SB  - AIM
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Afibrinogenemia/*complications
MH  - Aneurysm, Dissecting/*complications/diagnostic imaging/pathology/*surgery
MH  - Aorta, Thoracic/*pathology/surgery
MH  - Aortic Aneurysm/*pathology/surgery
MH  - Blood Coagulation Disorders/etiology/metabolism/mortality
MH  - Female
MH  - Fibrinogen/*metabolism/therapeutic use
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/etiology/metabolism/mortality
MH  - Perioperative Period/standards
MH  - Postoperative Complications/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tomography Scanners, X-Ray Computed
EDAT- 2018/05/26 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - 10.1097/MD.0000000000010830 [doi]
AID - 00005792-201805250-00049 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(21):e10830. doi: 10.1097/MD.0000000000010830.