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Effects of genetic variants on serum parathyroid hormone in hyperparathyroidism and end-stage renal disease patients: A systematic review and meta-analysis.

Abstract Parathyroid hormone (PTH) is one of the principal regulators of calcium homeostasis, crucial for normal functioning of the kidneys, bones, heart, and nervous system. Different pathologic conditions can affect serum PTH level resulting in hyperparathyroidism or hypoparathyroidism. Our study assessed the association of previously reported polymorphisms with the level of PTH (expressed in pg/mL) among individuals with different pathologic conditions affecting PTH level.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29794776
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 21
DP  - 2018 May
TI  - Effects of genetic variants on serum parathyroid hormone in hyperparathyroidism
      and end-stage renal disease patients: A systematic review and meta-analysis.
PG  - e10834
LID - 10.1097/MD.0000000000010834 [doi]
AB  - BACKGROUND: Parathyroid hormone (PTH) is one of the principal regulators of
      calcium homeostasis, crucial for normal functioning of the kidneys, bones, heart,
      and nervous system. Different pathologic conditions can affect serum PTH level
      resulting in hyperparathyroidism or hypoparathyroidism. Our study assessed the
      association of previously reported polymorphisms with the level of PTH (expressed
      in pg/mL) among individuals with different pathologic conditions affecting PTH
      level. METHODS: We searched Web of Science, MEDLINE, and Scopus to identify
      relevant articles published up to July 2017. The search yielded 6967 publications
      of which 44 fulfilled the inclusion criteria. We conducted meta-analyses for
      calcium-sensing receptor gene (CaSR) rs1801725 polymorphism in patients with
      primary hyperparathyroidism and vitamin D receptor gene (VDR) rs1544410
      polymorphism in patients with end-stage renal disease (ESRD). RESULTS: None of
      the polymorphisms were significantly associated with PTH levels in the overall
      population. In subgroup analysis by ethnicity for VDR rs1544410 gene
      polymorphism, we found significant differences under dominant model (SMD: -0.18
      [-0.32, -0.05], P < .01) and AA versus GG comparison (SMD: -0.29 [-0.52, -0.06], 
      P < .01) in Asian patients with ESRD, while nominally significant results (P <
      .05) were observed for AG versus GG and AA versus GG comparisons in European
      individuals with ESRD. CONCLUSION: Scientific evidence of genetic association of 
      serum PTH level among individuals with different pathologic conditions remains
      deficient and published results provide weak evidence. Further well-conducted
      studies on larger sample sets designed according to evidence-based principles are
      warranted to assure clinically applicable findings.
FAU - Matana, Antonela
AU  - Matana A
AD  - Department of Medical Biology, University of Split, School of Medicine.
FAU - Popovic, Marijana
AU  - Popovic M
AD  - Department of Medical Biology, University of Split, School of Medicine.
FAU - Torlak, Vesela
AU  - Torlak V
AD  - Department of Nuclear Medicine, University Hospital Split, Split, Croatia.
FAU - Punda, Ante
AU  - Punda A
AD  - Department of Nuclear Medicine, University Hospital Split, Split, Croatia.
FAU - Barbalic, Maja
AU  - Barbalic M
AD  - Department of Medical Biology, University of Split, School of Medicine.
FAU - Zemunik, Tatijana
AU  - Zemunik T
AD  - Department of Medical Biology, University of Split, School of Medicine.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Calcium-Sensing)
RN  - SY7Q814VUP (Calcium)
SB  - AIM
SB  - IM
MH  - Asian Continental Ancestry Group/genetics
MH  - Calcium/blood
MH  - Genotype
MH  - Humans
MH  - Hyperparathyroidism, Primary/blood/*genetics/pathology
MH  - Kidney Failure, Chronic/blood/*genetics/pathology
MH  - Parathyroid Hormone/*blood/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Receptors, Calcitriol/genetics
MH  - Receptors, Calcium-Sensing/genetics
EDAT- 2018/05/26 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - 10.1097/MD.0000000000010834 [doi]
AID - 00005792-201805250-00052 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(21):e10834. doi: 10.1097/MD.0000000000010834.