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Efficacy and safety of oral zinc sulfate in the prevention of chemotherapy-induced oral mucositis: Protocol for a meta-analysis of randomized controlled trials.

Abstract Oral mucositis has been an extremely serious complication resulted from cytotoxic effects of the chemotherapy among cancer patients. Several randomized controlled trials investigated the efficacy of zinc sulfate in prevention of this morbid condition among cancer patients undergoing chemotherapy, however conclusive findings has not yet been generated. This systematic review will assess the efficacy and safety of oral zinc sulfate for chemotherapy-induced oral mucositis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29794779
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 21
DP  - 2018 May
TI  - Efficacy and safety of oral zinc sulfate in the prevention of
      chemotherapy-induced oral mucositis: Protocol for a meta-analysis of randomized
      controlled trials.
PG  - e10839
LID - 10.1097/MD.0000000000010839 [doi]
AB  - BACKGROUND: Oral mucositis has been an extremely serious complication resulted
      from cytotoxic effects of the chemotherapy among cancer patients. Several
      randomized controlled trials investigated the efficacy of zinc sulfate in
      prevention of this morbid condition among cancer patients undergoing
      chemotherapy, however conclusive findings has not yet been generated. This
      systematic review will assess the efficacy and safety of oral zinc sulfate for
      chemotherapy-induced oral mucositis. METHODS: We will electronically search all
      potential citations in PubMed, EMBASE, and Cochrane Central Register of
      Controlled Trials (CENTRAL) from their inception to April 2018. The randomized
      controlled trials, which investigated the efficacy of oral zinc sulfate for
      chemotherapy-induced oral mucositis will be considered. We will assign 2
      independent investigators to perform search, screen citations, extract data, and 
      appraise risk of bias. And then, the primary investigator will adopt RevMan 5.3
      software to complete all statistical analyses. ETHICS AND DISSEMINATION: The
      findings from this systematic review and meta-analysis will be submitted to a
      peer-reviewed journal for publication. Moreover, we will disseminate all results 
      in any topic-related conference. REGISTRATION NUMBER: This protocol has been
      registered with a number of CRD42018093605.
FAU - Tian, Xu
AU  - Tian X
AD  - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and
      Individualized Treatment.
FAU - Chen, Wei-Qing
AU  - Chen WQ
AD  - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and
      Individualized Treatment.
AD  - Key Laboratory for Biorheological Science and Technology of Ministry of Education
      (Chongqing University), Chongqing University Cancer Hospital & Chongqing Cancer
      Institute & Chongqing Cancer Hospital, Chongqing, China.
FAU - Liu, Xiao-Ling
AU  - Liu XL
AD  - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and
      Individualized Treatment.
FAU - Pi, Yuan-Ping
AU  - Pi YP
AD  - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and
      Individualized Treatment.
AD  - Key Laboratory for Biorheological Science and Technology of Ministry of Education
      (Chongqing University), Chongqing University Cancer Hospital & Chongqing Cancer
      Institute & Chongqing Cancer Hospital, Chongqing, China.
FAU - Chen, Hui
AU  - Chen H
AD  - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and
      Individualized Treatment.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Astringents)
RN  - 7733-02-0 (Zinc Sulfate)
SB  - AIM
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - Astringents/administration & dosage/therapeutic use
MH  - Humans
MH  - Neoplasms/complications/drug therapy
MH  - Randomized Controlled Trials as Topic
MH  - Stomatitis/*chemically induced/*drug therapy/prevention & control
MH  - Zinc Sulfate/administration & dosage/*therapeutic use
EDAT- 2018/05/26 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - 10.1097/MD.0000000000010839 [doi]
AID - 00005792-201805250-00055 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(21):e10839. doi: 10.1097/MD.0000000000010839.