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Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation t (9;21) (p13; p11.2) in an infant acute lymphoblastic leukemia patient at relapse: A case report.

Abstract Three-way translocations occasionally occur in MLL-AFF1 fusion and other fusion gene. However, the complex chromosomal rearrangements in the study were the first report.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29794792
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 21
DP  - 2018 May
TI  - Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1
      and a second translocation [t (9;21) (p13; p11.2)] in an infant acute
      lymphoblastic leukemia patient at relapse: A case report.
PG  - e10874
LID - 10.1097/MD.0000000000010874 [doi]
AB  - RATIONALE: Three-way translocations occasionally occur in MLL-AFF1 fusion and
      other fusion gene. However, the complex chromosomal rearrangements in the study
      were the first report. PATIENT CONCERNS: We present novel cryptic and complex
      chromosomal rearrangements [der (21) t (9; 21) (p13; p11.2)] in an infant patient
      with relapsed acute lymphoblastic leukemia (ALL). DIAGNOSES: The diagnosis was
      based on morphologic, cytochemical, and immunophenotypic criteria proposed by the
      French-American-British Committee, and karyotype, fluorescence in situ
      hybridization, array comparative genomic hybridization. INTERVENTIONS: The
      patient was given chemotherapy with standard protocol for ALL. OUTCOMES: The
      patient had unfavorable prognostic outcome based on the cytogenetic and molecular
      cytogenetic markers. After short remission, the patient relapsed. LESSONS:
      MLL-AFF1, resulting from t(4;11)(q21;q23), is regarded as the hallmark of infant 
      t(4;11) pre-B/mixed B-ALL. It is associated with a dismal prognosis and the
      multiple-way translocation involving chromosomes 4, 11 and 11 may function as an 
      enhancer.
FAU - Liu, Guangming
AU  - Liu G
AD  - Department of Gastroenterology, The First Hospital of Jilin University,
      Changchun, People's Republic of China.
AD  - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma
      City, OK.
FAU - Lu, Xianglan
AU  - Lu X
AD  - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma
      City, OK.
FAU - Kim, Young Mi
AU  - Kim YM
AD  - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma
      City, OK.
FAU - Wang, Xianfu
AU  - Wang X
AD  - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma
      City, OK.
FAU - Li, Shibo
AU  - Li S
AD  - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma
      City, OK.
FAU - Liu, Yuanyuan
AU  - Liu Y
AD  - Department of Gastroenterology, The First Hospital of Jilin University,
      Changchun, People's Republic of China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MLL protein, human)
RN  - 0 (Transcriptional Elongation Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - 150826-18-9 (AFF1 protein, human)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - AIM
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 4/genetics
MH  - Comparative Genomic Hybridization/methods
MH  - Cytogenetic Analysis/methods
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Fusion
MH  - Histone-Lysine N-Methyltransferase/genetics
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Induction Chemotherapy/methods
MH  - Infant
MH  - Karyotyping
MH  - Male
MH  - Myeloid-Lymphoid Leukemia Protein/genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics
MH  - Recurrence
MH  - Transcriptional Elongation Factors/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2018/05/26 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - 10.1097/MD.0000000000010874 [doi]
AID - 00005792-201805250-00068 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(21):e10874. doi: 10.1097/MD.0000000000010874.