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Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.

Abstract Circular RNAs (circRNAs) have emerged as a novel class of widespread non-coding RNAs, and they play crucial roles in various biological processes. However, the characterization and function of circRNAs in infantile hemangioma (IH) remain elusive.
PMID
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Circular RNA profile of infantile hemangioma by microarray analysis.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29794795
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 21
DP  - 2018 May
TI  - Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.
PG  - e10882
LID - 10.1097/MD.0000000000010882 [doi]
AB  - BACKGROUND: Circular RNAs (circRNAs) have emerged as a novel class of widespread 
      non-coding RNAs, and they play crucial roles in various biological processes.
      However, the characterization and function of circRNAs in infantile hemangioma
      (IH) remain elusive. METHODS: In this study, we used RNA-Seq and circRNA
      prediction to study and characterize the circRNAs in IH tissue and a matched
      normal skin control. Specific circRNAs were verified using real-time polymerase
      chain reaction. RESULTS AND CONCLUSION: We found that of the 9811 identified
      circRNAs, 249 candidates were differentially expressed, including 124 upregulated
      and 125 downregulated circRNAs in the IH group compared with the matched normal
      skin control group. A set of differentially expressed circRNAs (in particular,
      hsa_circRNA001885 and hsa_circRNA006612 expression) were confirmed using qRT-PCR.
      Gene ontology and pathway analysis revealed that compared to matched normal skin 
      tissues, many processes that were over-represented in IH group were related to
      the binding, protein binding, gap junction, and focal adhesion. Specific circRNAs
      were associated with several micro-RNAs (miRNAs) predicted using miRanda.
      Altogether, our findings highlight the potential importance of circRNAs in the
      biology of IH and its response to treatment.
FAU - Li, Jun
AU  - Li J
AD  - Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical
      Institute, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical
      University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
FAU - Li, Qian
AU  - Li Q
FAU - Chen, Ling
AU  - Chen L
FAU - Gao, Yanli
AU  - Gao Y
FAU - Li, Jingyun
AU  - Li J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, circular)
RN  - 63231-63-0 (RNA)
SB  - AIM
SB  - IM
MH  - Biomarkers/metabolism
MH  - Down-Regulation
MH  - Female
MH  - Gene Ontology
MH  - Hemangioma/epidemiology/*genetics/physiopathology
MH  - Humans
MH  - Infant
MH  - Male
MH  - MicroRNAs/genetics
MH  - Microarray Analysis/methods
MH  - RNA/*genetics
MH  - Real-Time Polymerase Chain Reaction/methods
MH  - Sequence Analysis, RNA/*methods
MH  - Up-Regulation
MH  - Vascular Neoplasms/epidemiology/*genetics/physiopathology
EDAT- 2018/05/26 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
AID - 10.1097/MD.0000000000010882 [doi]
AID - 00005792-201805250-00071 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(21):e10882. doi: 10.1097/MD.0000000000010882.