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Pathology and pathogenesis of human leptospirosis: a commented review.

Abstract Leptospirosis is an acute bacterial septicemic febrile disease caused by pathogenic leptospires, which affect humans and animals in all parts of the world. Transmission can occur by direct contact with infected animals or, more commonly, through indirect contact with water or soil contaminated with urine from infected animals. Leptospires enter the body by penetrating mucous membranes or skin abrasions and disseminate through the hematogenic route. In humans, leptospirosis may cause a wide spectrum of symptoms. Most cases have a biphasic clinical presentation, which begins with the septicemic phase followed by immune manifestations. The severe forms of the disease may be life threatening with multisystem damage including renal failure, hepatic dysfunction, vascular damage, pulmonary hemorrhage and muscle lesions. In this review, we present and discuss the pathogenesis of the human disease and the mechanisms of cell membrane injuries, which occur mainly due to the presence of leptospires and/or their antigen/s in the host tissues.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title revista do instituto de medicina tropical de sao paulo
Publication Year Start




PMID- 29846473
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20180606
IS  - 1678-9946 (Electronic)
IS  - 0036-4665 (Linking)
VI  - 60
DP  - 2018
TI  - Pathology and pathogenesis of human leptospirosis: a commented review.
PG  - e23
LID - S0036-46652018005000400 [pii]
LID - 10.1590/s1678-9946201860023 [doi]
AB  - Leptospirosis is an acute bacterial septicemic febrile disease caused by
      pathogenic leptospires, which affect humans and animals in all parts of the
      world. Transmission can occur by direct contact with infected animals or, more
      commonly, through indirect contact with water or soil contaminated with urine
      from infected animals. Leptospires enter the body by penetrating mucous membranes
      or skin abrasions and disseminate through the hematogenic route. In humans,
      leptospirosis may cause a wide spectrum of symptoms. Most cases have a biphasic
      clinical presentation, which begins with the septicemic phase followed by immune 
      manifestations. The severe forms of the disease may be life threatening with
      multisystem damage including renal failure, hepatic dysfunction, vascular damage,
      pulmonary hemorrhage and muscle lesions. In this review, we present and discuss
      the pathogenesis of the human disease and the mechanisms of cell membrane
      injuries, which occur mainly due to the presence of leptospires and/or their
      antigen/s in the host tissues.
FAU - De Brito, Thales
AU  - De Brito T
AD  - Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Sao
      Paulo, Brazil.
FAU - Silva, Ana Maria Goncalves da
AU  - Silva AMGD
AD  - Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Sao
      Paulo, Brazil.
FAU - Abreu, Patricia Antonia Estima
AU  - Abreu PAE
AD  - Laboratorio de Bacteriologia, Instituto Butantan, Sao Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180528
PL  - Brazil
TA  - Rev Inst Med Trop Sao Paulo
JT  - Revista do Instituto de Medicina Tropical de Sao Paulo
JID - 7507484
RN  - 0 (Cadherins)
SB  - IM
MH  - Animals
MH  - Cadherins/*metabolism
MH  - Cell Membrane/*parasitology/pathology
MH  - Humans
MH  - Kidney/*parasitology/pathology
MH  - Leptospirosis/*etiology/metabolism/*pathology
MH  - Liver/*parasitology/pathology
MH  - Muscular Diseases/*parasitology/pathology
PMC - PMC5975557
EDAT- 2018/05/31 06:00
MHDA- 2018/06/06 06:00
CRDT- 2018/05/31 06:00
PHST- 2018/01/04 00:00 [received]
PHST- 2018/04/23 00:00 [accepted]
PHST- 2018/05/31 06:00 [entrez]
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
AID - S0036-46652018005000400 [pii]
AID - 10.1590/s1678-9946201860023 [doi]
PST - ppublish
SO  - Rev Inst Med Trop Sao Paulo. 2018;60:e23. doi: 10.1590/s1678-9946201860023. Epub 
      2018 May 28.