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Coagulation factor V gene 1691G>A polymorphism as an indicator for risk and prognosis of lower extremity deep venous thrombosis in Chinese Han population.

Abstract The purpose of this study was to explore the negative influence coagulation factor V (FV) 1691G>A polymorphism had on the risk and prognosis of lower extremity deep venous thrombosis (LDVT) in Chinese Han population.A total of 348 patients with LDVT (LDVT group) and 398 healthy individuals (control group) were selected to further this study. A polymerase chain reaction-restriction fragment length polymorphism method was used to analyze the FV gene 1691G>A polymorphism; coagulation and anticoagulation indexes of patients with LDVT were detected as a result. A 3-year follow-up and logistic regression analysis were conducted to determine the corresponding correlations between FV gene and LDVT.In comparison with the control group, the frequencies of GA and AA genotypes and A allele of 1691G>A polymorphism significantly increased in the LDVT group. Also, in comparison with patients with LDVT carrying GG genotype of FV gene 1691G>A polymorphism, the following activities reduced significantly: prothrombin time, activated partial thromboplastin time, fibrinogen, protein C, and protein S, while activated protein C resistance and lupus anticoagulant positive rate increased in patients carrying A allele (GA + AA). Logistic regression analysis indicated that FV gene 1691G>A polymorphism, total cholesterol, low-density lipoprotein cholesterol, and LDVT family histories were all closely related with LDVT and were subsequent independent risk factors for LDVT. Moreover, patients with LDVT carrying A allele (GA + AA) had both higher patency and recurrence rates than those carrying GG genotype.FV gene 1691G>A polymorphism may be associated with both the risk and prognosis of LDVT, potentially being a useful index for monitoring LDVT prognosis and risk.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29851809
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20180606
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 22
DP  - 2018 Jun
TI  - Coagulation factor V gene 1691G>A polymorphism as an indicator for risk and
      prognosis of lower extremity deep venous thrombosis in Chinese Han population.
PG  - e10885
LID - 10.1097/MD.0000000000010885 [doi]
AB  - The purpose of this study was to explore the negative influence coagulation
      factor V (FV) 1691G>A polymorphism had on the risk and prognosis of lower
      extremity deep venous thrombosis (LDVT) in Chinese Han population.A total of 348 
      patients with LDVT (LDVT group) and 398 healthy individuals (control group) were 
      selected to further this study. A polymerase chain reaction-restriction fragment 
      length polymorphism method was used to analyze the FV gene 1691G>A polymorphism; 
      coagulation and anticoagulation indexes of patients with LDVT were detected as a 
      result. A 3-year follow-up and logistic regression analysis were conducted to
      determine the corresponding correlations between FV gene and LDVT.In comparison
      with the control group, the frequencies of GA and AA genotypes and A allele of
      1691G>A polymorphism significantly increased in the LDVT group. Also, in
      comparison with patients with LDVT carrying GG genotype of FV gene 1691G>A
      polymorphism, the following activities reduced significantly: prothrombin time,
      activated partial thromboplastin time, fibrinogen, protein C, and protein S,
      while activated protein C resistance and lupus anticoagulant positive rate
      increased in patients carrying A allele (GA + AA). Logistic regression analysis
      indicated that FV gene 1691G>A polymorphism, total cholesterol, low-density
      lipoprotein cholesterol, and LDVT family histories were all closely related with 
      LDVT and were subsequent independent risk factors for LDVT. Moreover, patients
      with LDVT carrying A allele (GA + AA) had both higher patency and recurrence
      rates than those carrying GG genotype.FV gene 1691G>A polymorphism may be
      associated with both the risk and prognosis of LDVT, potentially being a useful
      index for monitoring LDVT prognosis and risk.
FAU - Zhang, Chang-Lie
AU  - Zhang CL
AD  - Department of Vascular Surgery, Linyi People's Hospital, Linyi, Shandong, China.
FAU - Li, Zun-Min
AU  - Li ZM
FAU - Song, Zhi-Hong
AU  - Song ZH
FAU - Song, Tao
AU  - Song T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 9001-24-5 (Factor V)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian Continental Ancestry Group/*genetics
MH  - Case-Control Studies
MH  - China/ethnology
MH  - Ethnic Groups/*genetics
MH  - Factor V/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Lower Extremity
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Prognosis
MH  - Recurrence
MH  - Risk Factors
MH  - Venous Thrombosis/ethnology/*genetics
MH  - Young Adult
EDAT- 2018/06/01 06:00
MHDA- 2018/06/07 06:00
CRDT- 2018/06/01 06:00
PHST- 2018/06/01 06:00 [entrez]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
AID - 10.1097/MD.0000000000010885 [doi]
AID - 00005792-201806010-00037 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jun;97(22):e10885. doi: 10.1097/MD.0000000000010885.