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Inhaled nitric oxide therapy was not associated with postoperative acute kidney injury in patients undergoing lung transplantation: A retrospective pilot study.

Abstract Inhaled nitric oxide (iNO) therapy is commonly used in lung transplantation (LT) recipients during the perioperative periods. However, previous studies report that the use of iNO may increase the risk of renal dysfunction. Post-LT acute kidney injury (AKI) can lead to critical situations, including prolonged intensive care unit or hospital stays and increased morbidity and mortality. Accordingly, the aim of this study was to investigate the relationship between iNO therapy and incidence of post-LT AKI in LT recipients.The medical data of 36 patients who underwent LT surgery from January 2012 to July 2017 in a single university hospital setting were retrospectively collected and analyzed. Patients were divided into 2 groups: iNO (n = 14) and control (n = 19). The demographic data, anesthetic methods, complications, and perioperative laboratory test values of each patient were assessed. Patients were categorized according to changes in plasma creatinine (Cr) concentration levels within 48 hours after LT using Acute Kidney Injury Network criteria.There was no significant difference in the occurrence (P = .13) and severity (P = .9) of post-LT AKI between iNO and control groups. The mean serum Cr levels after surgery were 0.91 ± 0.44 and 0.81 ± 0.37 mg/dL in the iNO and control groups, respectively (P = .50).AKI plays a critical role in the prognosis of LT recipients. Our results revealed that iNO therapy was not associated with the incidence of post-LT AKI. Therefore, if iNO treatment is indicated, active use under close monitoring of renal function is recommended in LT-patients concerned about AKI after surgery.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29851823
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20180611
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 22
DP  - 2018 Jun
TI  - Inhaled nitric oxide therapy was not associated with postoperative acute kidney
      injury in patients undergoing lung transplantation: A retrospective pilot study.
PG  - e10915
LID - 10.1097/MD.0000000000010915 [doi]
AB  - Inhaled nitric oxide (iNO) therapy is commonly used in lung transplantation (LT) 
      recipients during the perioperative periods. However, previous studies report
      that the use of iNO may increase the risk of renal dysfunction. Post-LT acute
      kidney injury (AKI) can lead to critical situations, including prolonged
      intensive care unit or hospital stays and increased morbidity and mortality.
      Accordingly, the aim of this study was to investigate the relationship between
      iNO therapy and incidence of post-LT AKI in LT recipients.The medical data of 36 
      patients who underwent LT surgery from January 2012 to July 2017 in a single
      university hospital setting were retrospectively collected and analyzed. Patients
      were divided into 2 groups: iNO (n = 14) and control (n = 19). The demographic
      data, anesthetic methods, complications, and perioperative laboratory test values
      of each patient were assessed. Patients were categorized according to changes in 
      plasma creatinine (Cr) concentration levels within 48 hours after LT using Acute 
      Kidney Injury Network criteria.There was no significant difference in the
      occurrence (P = .13) and severity (P = .9) of post-LT AKI between iNO and control
      groups. The mean serum Cr levels after surgery were 0.91 +/- 0.44 and 0.81 +/-
      0.37 mg/dL in the iNO and control groups, respectively (P = .50).AKI plays a
      critical role in the prognosis of LT recipients. Our results revealed that iNO
      therapy was not associated with the incidence of post-LT AKI. Therefore, if iNO
      treatment is indicated, active use under close monitoring of renal function is
      recommended in LT-patients concerned about AKI after surgery.
FAU - Ri, Hyun-Su
AU  - Ri HS
AD  - Department of Anesthesia and Pain Medicine, Pusan National University Yangsan
      Hospital, Yangsan.
FAU - Son, Hyo Jung
AU  - Son HJ
AD  - Department of Anesthesiology and Pain Medicine, National Police Hospital, Seoul, 
      Korea.
FAU - Oh, Han Byeol
AU  - Oh HB
AD  - Department of Anesthesiology and Pain Medicine, National Police Hospital, Seoul, 
      Korea.
FAU - Kim, Su-Young
AU  - Kim SY
AD  - Department of Anesthesia and Pain Medicine, Pusan National University Yangsan
      Hospital, Yangsan.
FAU - Park, Ju Yeon
AU  - Park JY
AD  - Department of Anesthesia and Pain Medicine, Pusan National University Yangsan
      Hospital, Yangsan.
FAU - Kim, Ju Yeon
AU  - Kim JY
AD  - Department of Anesthesia and Pain Medicine, Pusan National University Yangsan
      Hospital, Yangsan.
FAU - Choi, Yoon Ji
AU  - Choi YJ
AD  - Department of Anesthesia and Pain Medicine, Pusan National University Yangsan
      Hospital, Yangsan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Bronchodilator Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - AIM
SB  - IM
MH  - Acute Kidney Injury/*chemically induced/epidemiology
MH  - Administration, Inhalation
MH  - Bronchodilator Agents/administration & dosage/*adverse effects
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kidney Function Tests
MH  - Lung Transplantation/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/administration & dosage/*adverse effects
MH  - Pilot Projects
MH  - Postoperative Complications/*chemically induced/epidemiology
MH  - Postoperative Period
MH  - Respiratory Therapy/*adverse effects
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2018/06/01 06:00
MHDA- 2018/06/12 06:00
CRDT- 2018/06/01 06:00
PHST- 2018/06/01 06:00 [entrez]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
AID - 10.1097/MD.0000000000010915 [doi]
AID - 00005792-201806010-00051 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jun;97(22):e10915. doi: 10.1097/MD.0000000000010915.